Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.

Conceição, Mariana

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype. [electronic resource] - Biomaterials Mar 2016 - 124-37 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-5905

10.1016/j.biomaterials.2015.12.021 doi


Animals
Brain--drug effects
Drug Stability
Gene Silencing
Injections, Intravenous
Lipids--chemistry
Liposomes--chemistry
Machado-Joseph Disease--genetics
Mice
Mice, Inbred C57BL
Nucleic Acids--administration & dosage
Particle Size
Phenotype
RNA, Small Interfering--administration & dosage
Treatment Outcome