HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK.

Gschwantler-Kaulich, Daphne

HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK. [electronic resource] - PloS one 2016 - e0146311 p. digital

Publication Type: Journal Article

1932-6203

10.1371/journal.pone.0146311 doi


Afatinib
Antineoplastic Agents--pharmacology
Apoptosis
Breast Neoplasms--drug therapy
Cell Line, Tumor
Cell Proliferation
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
ErbB Receptors--antagonists & inhibitors
Female
Humans
Inhibitory Concentration 50
JNK Mitogen-Activated Protein Kinases--metabolism
Lapatinib
MAP Kinase Signaling System
Morpholines--pharmacology
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Protein Processing, Post-Translational
Quinazolines--pharmacology
STAT5 Transcription Factor--metabolism