Exogenous Hsp70 delays senescence and improves cognitive function in aging mice.

Bobkova, Natalia V

Exogenous Hsp70 delays senescence and improves cognitive function in aging mice. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Dec 2015 - 16006-11 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1091-6490

10.1073/pnas.1516131112 doi


Aging--drug effects
Animals
Blotting, Western
Brain--cytology
Cognition--drug effects
Exploratory Behavior--drug effects
HSP70 Heat-Shock Proteins--genetics
Humans
Lipofuscin--metabolism
Longevity--drug effects
Male
Maze Learning--drug effects
Memory--drug effects
Mice, Inbred Strains
Microscopy, Fluorescence
Motor Activity--drug effects
Proteasome Endopeptidase Complex--metabolism
Protein Subunits--metabolism
Recombinant Proteins--pharmacology
Synaptophysin--metabolism