Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study.
Chanan-Khan, Asher
Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study. [electronic resource] - The Lancet. Oncology Feb 2016 - 200-211 p. digital
Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1474-5488
10.1016/S1470-2045(15)00465-9 doi
Adenine--analogs & derivatives
Adult
Aged
Aged, 80 and over
Anemia--chemically induced
Antineoplastic Combined Chemotherapy Protocols--adverse effects
Atrial Fibrillation--chemically induced
Bendamustine Hydrochloride--administration & dosage
Disease Progression
Disease-Free Survival
Double-Blind Method
Female
Hemorrhage--chemically induced
Humans
Intention to Treat Analysis
Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy
Male
Middle Aged
Nausea--chemically induced
Neutropenia--chemically induced
Piperidines
Pyrazoles--administration & dosage
Pyrimidines--administration & dosage
Retreatment
Rituximab--administration & dosage
Thrombocytopenia--chemically induced
Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study. [electronic resource] - The Lancet. Oncology Feb 2016 - 200-211 p. digital
Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1474-5488
10.1016/S1470-2045(15)00465-9 doi
Adenine--analogs & derivatives
Adult
Aged
Aged, 80 and over
Anemia--chemically induced
Antineoplastic Combined Chemotherapy Protocols--adverse effects
Atrial Fibrillation--chemically induced
Bendamustine Hydrochloride--administration & dosage
Disease Progression
Disease-Free Survival
Double-Blind Method
Female
Hemorrhage--chemically induced
Humans
Intention to Treat Analysis
Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy
Male
Middle Aged
Nausea--chemically induced
Neutropenia--chemically induced
Piperidines
Pyrazoles--administration & dosage
Pyrimidines--administration & dosage
Retreatment
Rituximab--administration & dosage
Thrombocytopenia--chemically induced