Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes.

Wang, Wenzhang

Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. [electronic resource] - Nature medicine Jan 2016 - 54-63 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1546-170X

10.1038/nm.3983 doi


Aged
Aged, 80 and over
Animals
Blotting, Western
Cell Line, Tumor
Dynamins--metabolism
Female
Fluorescence Recovery After Photobleaching
Fluorescent Antibody Technique
GTP Phosphohydrolases--metabolism
Gene Knockdown Techniques
Humans
In Vitro Techniques
Male
Mice
Microscopy, Electron, Transmission
Microscopy, Immunoelectron
Microtubule-Associated Proteins--metabolism
Mitochondria--metabolism
Mitochondrial Dynamics--genetics
Mitochondrial Proteins--metabolism
Neurons
Oxidative Stress
Parkinson Disease--genetics
Rats
Substantia Nigra--cytology
Time-Lapse Imaging
Vesicular Transport Proteins--genetics