Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway.

Liu, Maoxi

Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. [electronic resource] - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine May 2016 - 6155-68 p. digital

Publication Type: Journal Article

1423-0380

10.1007/s13277-015-4348-4 doi


Aged
Aged, 80 and over
Apoptosis--drug effects
Biomarkers, Tumor
Cell Hypoxia
Cell Line, Tumor
Colonic Neoplasms--genetics
Enzyme Activation
Enzyme Inhibitors--pharmacology
Female
Gene Expression
Humans
Inhibitor of Apoptosis Proteins--genetics
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Phosphatidylinositol 3-Kinases--metabolism
Phospholipase D--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-bcl-2--genetics
Signal Transduction
Survivin