The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.

Park, Jihye

The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Jan 2016 - 244-55 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1550-6606

10.4049/jimmunol.1403099 doi


Animals
Apoptosis--genetics
B-Lymphocytes--immunology
Base Sequence
Cell Proliferation
Cells, Cultured
Cytidine Deaminase--metabolism
DNA Breaks, Double-Stranded
DNA End-Joining Repair--genetics
DNA Ligase ATP
DNA Ligases--genetics
Disease Models, Animal
Eczema--genetics
Facies
Gene Knock-In Techniques
Growth Disorders--genetics
Humans
Immunoglobulin A--blood
Immunoglobulin Class Switching--genetics
Immunoglobulin E--blood
Immunoglobulin G--blood
Immunoglobulin Variable Region--genetics
Immunoglobulins--genetics
Intellectual Disability--genetics
Lymphopoiesis--genetics
Mice
Mice, Knockout
Microcephaly--genetics
Molecular Sequence Data
Severe Combined Immunodeficiency--genetics
Tumor Suppressor Protein p53--genetics