Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling.

Koehler, Bruno Christian

Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling. [electronic resource] - BMC cancer Nov 2015 - 919 p. digital

Publication Type: Journal Article

1471-2407

10.1186/s12885-015-1929-y doi


Antineoplastic Agents--pharmacology
Autophagy--drug effects
Biphenyl Compounds--pharmacology
Cell Culture Techniques
Cell Line, Tumor
Cell Proliferation--drug effects
Colorectal Neoplasms--drug therapy
Gene Expression Regulation, Neoplastic--drug effects
HT29 Cells
Humans
Indoles
Nitrophenols--pharmacology
Piperazines--pharmacology
Proto-Oncogene Proteins c-bcl-2--genetics
Pyrroles--pharmacology
Signal Transduction--drug effects
Sulfonamides--pharmacology