Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells.

Zi, Dan

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells. [electronic resource] - International journal of molecular sciences Nov 2015 - 27228-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1422-0067

10.3390/ijms161126018 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Autophagy--drug effects
Benzamides--pharmacology
Cell Cycle Checkpoints--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Epithelial-Mesenchymal Transition--drug effects
Female
Humans
Mitochondria--drug effects
Ovarian Neoplasms--metabolism
Phenotype
Phosphatidylinositol 3-Kinases--metabolism
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Pyrazoles--pharmacology
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--metabolism