Vorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK Pathways.

Sampson, Valerie B

Vorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK Pathways. [electronic resource] - PloS one 2015 - e0142704 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0142704 doi


Acetylation--drug effects
Antineoplastic Agents--toxicity
Apoptosis--drug effects
Camptothecin--analogs & derivatives
Caspase 3--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
DNA Damage--drug effects
Dacarbazine--analogs & derivatives
G1 Phase Cell Cycle Checkpoints--drug effects
Heterocyclic Compounds, 3-Ring--pharmacology
Histone Deacetylase Inhibitors--toxicity
Humans
Hydroxamic Acids--toxicity
Irinotecan
Mitogen-Activated Protein Kinases--metabolism
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Reactive Oxygen Species--metabolism
STAT3 Transcription Factor--antagonists & inhibitors
Sarcoma, Ewing--metabolism
Signal Transduction--drug effects
Temozolomide
Tumor Suppressor Protein p53--metabolism
Vorinostat