Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer.
Zhu, Yan
Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer. [electronic resource] - BMC cancer Nov 2015 - 894 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1471-2407
10.1186/s12885-015-1900-y doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Imidazoles--pharmacology
Mice
Phosphoinositide-3 Kinase Inhibitors
Quinolines--pharmacology
Receptor, ErbB-2--metabolism
Signal Transduction--drug effects
Stomach Neoplasms--drug therapy
TOR Serine-Threonine Kinases--antagonists & inhibitors
Trastuzumab--pharmacology
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer. [electronic resource] - BMC cancer Nov 2015 - 894 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1471-2407
10.1186/s12885-015-1900-y doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Imidazoles--pharmacology
Mice
Phosphoinositide-3 Kinase Inhibitors
Quinolines--pharmacology
Receptor, ErbB-2--metabolism
Signal Transduction--drug effects
Stomach Neoplasms--drug therapy
TOR Serine-Threonine Kinases--antagonists & inhibitors
Trastuzumab--pharmacology
Tumor Burden--drug effects
Xenograft Model Antitumor Assays