Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway.

Xiao, Wenqin

Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway. [electronic resource] - PloS one 2015 - e0141462 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0141462 doi


Actins--biosynthesis
Active Transport, Cell Nucleus--drug effects
Animals
Apoptosis--drug effects
Axin Protein--biosynthesis
Cells, Cultured
Ceruletide--toxicity
Collagen Type I--biosynthesis
Disease Progression
Drug Evaluation, Preclinical
Fibrosis--prevention & control
Gene Expression Regulation--drug effects
Lipase--blood
Male
Mice
Mice, Inbred BALB C
Organ Size--drug effects
Pancreas--drug effects
Pancreatic Stellate Cells--drug effects
Pancreatic alpha-Amylases--blood
Pancreatitis, Chronic--chemically induced
Proteoglycans--biosynthesis
RNA, Messenger--biosynthesis
Random Allocation
Receptor, Platelet-Derived Growth Factor beta--biosynthesis
Receptors, Transforming Growth Factor beta--biosynthesis
Tretinoin--pharmacology
Wnt Signaling Pathway--drug effects