Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. [electronic resource] - Nature genetics Dec 2015 - 1415-25 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1546-1718
10.1038/ng.3437 doi
Binding Sites
Case-Control Studies
Chromatin Immunoprecipitation
Chromosome Mapping
Diabetes Mellitus, Type 2--genetics
Gene Expression Regulation
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomics
Hepatocyte Nuclear Factor 3-beta--genetics
Humans
Islets of Langerhans--metabolism
Liver--metabolism
Molecular Sequence Annotation
Polymorphism, Single Nucleotide--genetics
Receptor, Melatonin, MT2--genetics
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
APA
Gaulton K. J., Ferreira T., Lee Y., Raimondo A., Mägi R., Reschen M. E., Mahajan A., Locke A., Rayner N. W., Robertson N., Scott R. A., Prokopenko I., Scott L. J., Green T., Sparso T., Thuillier D., Yengo L., Grallert H., Wahl S., Frånberg M., Strawbridge R. J., Kestler H., Chheda H., Eisele L., Gustafsson S., Steinthorsdottir V., Thorleifsson G., Qi L., Karssen L. C., van Leeuwen E. M., Willems S. M., Li M., Chen H., Fuchsberger C., Kwan P., Ma C., Linderman M., Lu Y., Thomsen S. K., Rundle J. K., Beer N. L., van de Bunt M., Chalisey A., Kang H. M., Voight B. F., Abecasis G. R., Almgren P., Baldassarre D., Balkau B., Benediktsson R., Blüher M., Boeing H., Bonnycastle L. L., Bottinger E. P., Burtt N. P., Carey J., Charpentier G., Chines P. S., Cornelis M. C., Couper D. J., Crenshaw A. T., van Dam R. M., Doney A. S. F., Dorkhan M., Edkins S., Eriksson J. G., Esko T., Eury E., Fadista J., Flannick J., Fontanillas P., Fox C., Franks P. W., Gertow K., Gieger C., Gigante B., Gottesman O., Grant G. B., Grarup N., Groves C. J., Hassinen M., Have C. T., Herder C., Holmen O. L., Hreidarsson A. B., Humphries S. E., Hunter D. J., Jackson A. U., Jonsson A., Jørgensen M. E., Jørgensen T., Kao W. L., Kerrison N. D., Kinnunen L., Klopp N., Kong A., Kovacs P., Kraft P., Kravic J., Langford C., Leander K., Liang L., Lichtner P., Lindgren C. M., Lindholm E., Linneberg A., Liu C., Lobbens S., Luan J., Lyssenko V., Männistö S., McLeod O., Meyer J., Mihailov E., Mirza G., Mühleisen T. W., Müller-Nurasyid M., Navarro C., Nöthen M. M., Oskolkov N. N., Owen K. R., Palli D., Pechlivanis S., Peltonen L., Perry J. R. B., Platou C. G. P., Roden M., Ruderfer D., Rybin D., van der Schouw Y. T., Sennblad B., Sigurðsson G., Stančáková A., Steinbach G., Storm P., Strauch K., Stringham H. M., Sun Q., Thorand B., Tikkanen E., Tonjes A., Trakalo J., Tremoli E., Tuomi T., Wennauer R., Wiltshire S., Wood A. R., Zeggini E., Dunham I., Birney E., Pasquali L., Ferrer J., Loos R. J. F., Dupuis J., Florez J. C., Boerwinkle E., Pankow J. S., van Duijn C., Sijbrands E., Meigs J. B., Hu F. B., Thorsteinsdottir U., Stefansson K., Lakka T. A., Rauramaa R., Stumvoll M., Pedersen N. L., Lind L., Keinanen-Kiukaanniemi S. M., Korpi-Hyövälti E., Saaristo T. E., Saltevo J., Kuusisto J., Laakso M., Metspalu A., Erbel R., Jöcke K., Moebus S., Ripatti S., Salomaa V., Ingelsson E., Boehm B. O., Bergman R. N., Collins F. S., Mohlke K. L., Koistinen H., Tuomilehto J., Hveem K., Njølstad I., Deloukas P., Donnelly P. J., Frayling T. M., Hattersley A. T., de Faire U., Hamsten A., Illig T., Peters A., Cauchi S., Sladek R., Froguel P., Hansen T., Pedersen O., Morris A. D., Palmer C. N. A., Kathiresan S., Melander O., Nilsson P. M., Groop L. C., Barroso I., Langenberg C., Wareham N. J., O'Callaghan C. A., Gloyn A. L., Altshuler D., Boehnke M., Teslovich T. M., McCarthy M. I. & Morris A. P. (20160621). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. : Nature genetics.
Chicago
Gaulton Kyle J, Ferreira Teresa, Lee Yeji, Raimondo Anne, Mägi Reedik, Reschen Michael E, Mahajan Anubha, Locke Adam, Rayner N William, Robertson Neil, Scott Robert A, Prokopenko Inga, Scott Laura J, Green Todd, Sparso Thomas, Thuillier Dorothee, Yengo Loic, Grallert Harald, Wahl Simone, Frånberg Mattias, Strawbridge Rona J, Kestler Hans, Chheda Himanshu, Eisele Lewin, Gustafsson Stefan, Steinthorsdottir Valgerdur, Thorleifsson Gudmar, Qi Lu, Karssen Lennart C, van Leeuwen Elisabeth M, Willems Sara M, Li Man, Chen Han, Fuchsberger Christian, Kwan Phoenix, Ma Clement, Linderman Michael, Lu Yingchang, Thomsen Soren K, Rundle Jana K, Beer Nicola L, van de Bunt Martijn, Chalisey Anil, Kang Hyun Min, Voight Benjamin F, Abecasis Gonçalo R, Almgren Peter, Baldassarre Damiano, Balkau Beverley, Benediktsson Rafn, Blüher Matthias, Boeing Heiner, Bonnycastle Lori L, Bottinger Erwin P, Burtt Noël P, Carey Jason, Charpentier Guillaume, Chines Peter S, Cornelis Marilyn C, Couper David J, Crenshaw Andrew T, van Dam Rob M, Doney Alex S F, Dorkhan Mozhgan, Edkins Sarah, Eriksson Johan G, Esko Tonu, Eury Elodie, Fadista João, Flannick Jason, Fontanillas Pierre, Fox Caroline, Franks Paul W, Gertow Karl, Gieger Christian, Gigante Bruna, Gottesman Omri, Grant George B, Grarup Niels, Groves Christopher J, Hassinen Maija, Have Christian T, Herder Christian, Holmen Oddgeir L, Hreidarsson Astradur B, Humphries Steve E, Hunter David J, Jackson Anne U, Jonsson Anna, Jørgensen Marit E, Jørgensen Torben, Kao Wen-Hong L, Kerrison Nicola D, Kinnunen Leena, Klopp Norman, Kong Augustine, Kovacs Peter, Kraft Peter, Kravic Jasmina, Langford Cordelia, Leander Karin, Liang Liming, Lichtner Peter, Lindgren Cecilia M, Lindholm Eero, Linneberg Allan, Liu Ching-Ti, Lobbens Stéphane, Luan Jian'an, Lyssenko Valeriya, Männistö Satu, McLeod Olga, Meyer Julia, Mihailov Evelin, Mirza Ghazala, Mühleisen Thomas W, Müller-Nurasyid Martina, Navarro Carmen, Nöthen Markus M, Oskolkov Nikolay N, Owen Katharine R, Palli Domenico, Pechlivanis Sonali, Peltonen Leena, Perry John R B, Platou Carl G P, Roden Michael, Ruderfer Douglas, Rybin Denis, van der Schouw Yvonne T, Sennblad Bengt, Sigurðsson Gunnar, Stančáková Alena, Steinbach Gerald, Storm Petter, Strauch Konstantin, Stringham Heather M, Sun Qi, Thorand Barbara, Tikkanen Emmi, Tonjes Anke, Trakalo Joseph, Tremoli Elena, Tuomi Tiinamaija, Wennauer Roman, Wiltshire Steven, Wood Andrew R, Zeggini Eleftheria, Dunham Ian, Birney Ewan, Pasquali Lorenzo, Ferrer Jorge, Loos Ruth J F, Dupuis Josée, Florez Jose C, Boerwinkle Eric, Pankow James S, van Duijn Cornelia, Sijbrands Eric, Meigs James B, Hu Frank B, Thorsteinsdottir Unnur, Stefansson Kari, Lakka Timo A, Rauramaa Rainer, Stumvoll Michael, Pedersen Nancy L, Lind Lars, Keinanen-Kiukaanniemi Sirkka M, Korpi-Hyövälti Eeva, Saaristo Timo E, Saltevo Juha, Kuusisto Johanna, Laakso Markku, Metspalu Andres, Erbel Raimund, Jöcke Karl-Heinz, Moebus Susanne, Ripatti Samuli, Salomaa Veikko, Ingelsson Erik, Boehm Bernhard O, Bergman Richard N, Collins Francis S, Mohlke Karen L, Koistinen Heikki, Tuomilehto Jaakko, Hveem Kristian, Njølstad Inger, Deloukas Panagiotis, Donnelly Peter J, Frayling Timothy M, Hattersley Andrew T, de Faire Ulf, Hamsten Anders, Illig Thomas, Peters Annette, Cauchi Stephane, Sladek Rob, Froguel Philippe, Hansen Torben, Pedersen Oluf, Morris Andrew D, Palmer Collin N A, Kathiresan Sekar, Melander Olle, Nilsson Peter M, Groop Leif C, Barroso Inês, Langenberg Claudia, Wareham Nicholas J, O'Callaghan Christopher A, Gloyn Anna L, Altshuler David, Boehnke Michael, Teslovich Tanya M, McCarthy Mark I and Morris Andrew P. 20160621. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. : Nature genetics.
Harvard
Gaulton K. J., Ferreira T., Lee Y., Raimondo A., Mägi R., Reschen M. E., Mahajan A., Locke A., Rayner N. W., Robertson N., Scott R. A., Prokopenko I., Scott L. J., Green T., Sparso T., Thuillier D., Yengo L., Grallert H., Wahl S., Frånberg M., Strawbridge R. J., Kestler H., Chheda H., Eisele L., Gustafsson S., Steinthorsdottir V., Thorleifsson G., Qi L., Karssen L. C., van Leeuwen E. M., Willems S. M., Li M., Chen H., Fuchsberger C., Kwan P., Ma C., Linderman M., Lu Y., Thomsen S. K., Rundle J. K., Beer N. L., van de Bunt M., Chalisey A., Kang H. M., Voight B. F., Abecasis G. R., Almgren P., Baldassarre D., Balkau B., Benediktsson R., Blüher M., Boeing H., Bonnycastle L. L., Bottinger E. P., Burtt N. P., Carey J., Charpentier G., Chines P. S., Cornelis M. C., Couper D. J., Crenshaw A. T., van Dam R. M., Doney A. S. F., Dorkhan M., Edkins S., Eriksson J. G., Esko T., Eury E., Fadista J., Flannick J., Fontanillas P., Fox C., Franks P. W., Gertow K., Gieger C., Gigante B., Gottesman O., Grant G. B., Grarup N., Groves C. J., Hassinen M., Have C. T., Herder C., Holmen O. L., Hreidarsson A. B., Humphries S. E., Hunter D. J., Jackson A. U., Jonsson A., Jørgensen M. E., Jørgensen T., Kao W. L., Kerrison N. D., Kinnunen L., Klopp N., Kong A., Kovacs P., Kraft P., Kravic J., Langford C., Leander K., Liang L., Lichtner P., Lindgren C. M., Lindholm E., Linneberg A., Liu C., Lobbens S., Luan J., Lyssenko V., Männistö S., McLeod O., Meyer J., Mihailov E., Mirza G., Mühleisen T. W., Müller-Nurasyid M., Navarro C., Nöthen M. M., Oskolkov N. N., Owen K. R., Palli D., Pechlivanis S., Peltonen L., Perry J. R. B., Platou C. G. P., Roden M., Ruderfer D., Rybin D., van der Schouw Y. T., Sennblad B., Sigurðsson G., Stančáková A., Steinbach G., Storm P., Strauch K., Stringham H. M., Sun Q., Thorand B., Tikkanen E., Tonjes A., Trakalo J., Tremoli E., Tuomi T., Wennauer R., Wiltshire S., Wood A. R., Zeggini E., Dunham I., Birney E., Pasquali L., Ferrer J., Loos R. J. F., Dupuis J., Florez J. C., Boerwinkle E., Pankow J. S., van Duijn C., Sijbrands E., Meigs J. B., Hu F. B., Thorsteinsdottir U., Stefansson K., Lakka T. A., Rauramaa R., Stumvoll M., Pedersen N. L., Lind L., Keinanen-Kiukaanniemi S. M., Korpi-Hyövälti E., Saaristo T. E., Saltevo J., Kuusisto J., Laakso M., Metspalu A., Erbel R., Jöcke K., Moebus S., Ripatti S., Salomaa V., Ingelsson E., Boehm B. O., Bergman R. N., Collins F. S., Mohlke K. L., Koistinen H., Tuomilehto J., Hveem K., Njølstad I., Deloukas P., Donnelly P. J., Frayling T. M., Hattersley A. T., de Faire U., Hamsten A., Illig T., Peters A., Cauchi S., Sladek R., Froguel P., Hansen T., Pedersen O., Morris A. D., Palmer C. N. A., Kathiresan S., Melander O., Nilsson P. M., Groop L. C., Barroso I., Langenberg C., Wareham N. J., O'Callaghan C. A., Gloyn A. L., Altshuler D., Boehnke M., Teslovich T. M., McCarthy M. I. and Morris A. P. (20160621). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. : Nature genetics.
MLA
Gaulton Kyle J, Ferreira Teresa, Lee Yeji, Raimondo Anne, Mägi Reedik, Reschen Michael E, Mahajan Anubha, Locke Adam, Rayner N William, Robertson Neil, Scott Robert A, Prokopenko Inga, Scott Laura J, Green Todd, Sparso Thomas, Thuillier Dorothee, Yengo Loic, Grallert Harald, Wahl Simone, Frånberg Mattias, Strawbridge Rona J, Kestler Hans, Chheda Himanshu, Eisele Lewin, Gustafsson Stefan, Steinthorsdottir Valgerdur, Thorleifsson Gudmar, Qi Lu, Karssen Lennart C, van Leeuwen Elisabeth M, Willems Sara M, Li Man, Chen Han, Fuchsberger Christian, Kwan Phoenix, Ma Clement, Linderman Michael, Lu Yingchang, Thomsen Soren K, Rundle Jana K, Beer Nicola L, van de Bunt Martijn, Chalisey Anil, Kang Hyun Min, Voight Benjamin F, Abecasis Gonçalo R, Almgren Peter, Baldassarre Damiano, Balkau Beverley, Benediktsson Rafn, Blüher Matthias, Boeing Heiner, Bonnycastle Lori L, Bottinger Erwin P, Burtt Noël P, Carey Jason, Charpentier Guillaume, Chines Peter S, Cornelis Marilyn C, Couper David J, Crenshaw Andrew T, van Dam Rob M, Doney Alex S F, Dorkhan Mozhgan, Edkins Sarah, Eriksson Johan G, Esko Tonu, Eury Elodie, Fadista João, Flannick Jason, Fontanillas Pierre, Fox Caroline, Franks Paul W, Gertow Karl, Gieger Christian, Gigante Bruna, Gottesman Omri, Grant George B, Grarup Niels, Groves Christopher J, Hassinen Maija, Have Christian T, Herder Christian, Holmen Oddgeir L, Hreidarsson Astradur B, Humphries Steve E, Hunter David J, Jackson Anne U, Jonsson Anna, Jørgensen Marit E, Jørgensen Torben, Kao Wen-Hong L, Kerrison Nicola D, Kinnunen Leena, Klopp Norman, Kong Augustine, Kovacs Peter, Kraft Peter, Kravic Jasmina, Langford Cordelia, Leander Karin, Liang Liming, Lichtner Peter, Lindgren Cecilia M, Lindholm Eero, Linneberg Allan, Liu Ching-Ti, Lobbens Stéphane, Luan Jian'an, Lyssenko Valeriya, Männistö Satu, McLeod Olga, Meyer Julia, Mihailov Evelin, Mirza Ghazala, Mühleisen Thomas W, Müller-Nurasyid Martina, Navarro Carmen, Nöthen Markus M, Oskolkov Nikolay N, Owen Katharine R, Palli Domenico, Pechlivanis Sonali, Peltonen Leena, Perry John R B, Platou Carl G P, Roden Michael, Ruderfer Douglas, Rybin Denis, van der Schouw Yvonne T, Sennblad Bengt, Sigurðsson Gunnar, Stančáková Alena, Steinbach Gerald, Storm Petter, Strauch Konstantin, Stringham Heather M, Sun Qi, Thorand Barbara, Tikkanen Emmi, Tonjes Anke, Trakalo Joseph, Tremoli Elena, Tuomi Tiinamaija, Wennauer Roman, Wiltshire Steven, Wood Andrew R, Zeggini Eleftheria, Dunham Ian, Birney Ewan, Pasquali Lorenzo, Ferrer Jorge, Loos Ruth J F, Dupuis Josée, Florez Jose C, Boerwinkle Eric, Pankow James S, van Duijn Cornelia, Sijbrands Eric, Meigs James B, Hu Frank B, Thorsteinsdottir Unnur, Stefansson Kari, Lakka Timo A, Rauramaa Rainer, Stumvoll Michael, Pedersen Nancy L, Lind Lars, Keinanen-Kiukaanniemi Sirkka M, Korpi-Hyövälti Eeva, Saaristo Timo E, Saltevo Juha, Kuusisto Johanna, Laakso Markku, Metspalu Andres, Erbel Raimund, Jöcke Karl-Heinz, Moebus Susanne, Ripatti Samuli, Salomaa Veikko, Ingelsson Erik, Boehm Bernhard O, Bergman Richard N, Collins Francis S, Mohlke Karen L, Koistinen Heikki, Tuomilehto Jaakko, Hveem Kristian, Njølstad Inger, Deloukas Panagiotis, Donnelly Peter J, Frayling Timothy M, Hattersley Andrew T, de Faire Ulf, Hamsten Anders, Illig Thomas, Peters Annette, Cauchi Stephane, Sladek Rob, Froguel Philippe, Hansen Torben, Pedersen Oluf, Morris Andrew D, Palmer Collin N A, Kathiresan Sekar, Melander Olle, Nilsson Peter M, Groop Leif C, Barroso Inês, Langenberg Claudia, Wareham Nicholas J, O'Callaghan Christopher A, Gloyn Anna L, Altshuler David, Boehnke Michael, Teslovich Tanya M, McCarthy Mark I and Morris Andrew P. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. : Nature genetics. 20160621.