A biotherapy based on PSCs-in-3D spheroid-ameliorated biologics depletes in vivo cancer-sustaining stem cells.

Zhang, Wenhui

A biotherapy based on PSCs-in-3D spheroid-ameliorated biologics depletes in vivo cancer-sustaining stem cells. [electronic resource] - Oncotarget Dec 2015 - 40762-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1949-2553

10.18632/oncotarget.5691 doi


Animals
Apoptosis
Biological Products--administration & dosage
Biological Therapy
Blotting, Western
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Neoplasms--metabolism
Neoplastic Stem Cells--metabolism
RNA, Messenger--genetics
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Spheroids, Cellular--metabolism
Thymus Gland--cytology
Tumor Cells, Cultured
Wnt Signaling Pathway
Xenograft Model Antitumor Assays
beta Catenin--genetics