Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases.

Romero, Diana

Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases. [electronic resource] - Carcinogenesis Jan 2016 - 18-29 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2180

10.1093/carcin/bgv153 doi


Acinar Cells--metabolism
Adaptor Proteins, Signal Transducing
Cell Line, Tumor
Chemokines
Enzyme Activation
Epithelial Cells--metabolism
Gene Silencing
Humans
Intercellular Signaling Peptides and Proteins--genetics
Male
Matrix Metalloproteinase 2--biosynthesis
Matrix Metalloproteinase 9--biosynthesis
Morphogenesis
Neoplasm Invasiveness
Prostatic Neoplasms--enzymology
Protein Structure, Tertiary
Signal Transduction
Transforming Growth Factor beta--metabolism