Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.

Clemens, Laura E

Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat. [electronic resource] - Brain : a journal of neurology Dec 2015 - 3632-53 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2156

10.1093/brain/awv290 doi


Animals
Behavior, Animal--drug effects
Brain--drug effects
Calpain--antagonists & inhibitors
Cholestenones--blood
Disease Models, Animal
Enzyme Activation--drug effects
Huntingtin Protein
Huntington Disease--drug therapy
Male
Mitochondria--drug effects
Mutant Proteins--chemistry
Mutation
Nerve Tissue Proteins--chemistry
Nuclear Proteins--chemistry
Proteolysis--drug effects
Rats
Rats, Transgenic