Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease.

Ngoh, Eyler N

Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease. [electronic resource] - Gastroenterology Feb 2016 - 465-76 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1528-0012

10.1053/j.gastro.2015.09.049 doi


Animals
Anti-Inflammatory Agents--pharmacology
Cells, Cultured
Class I Phosphatidylinositol 3-Kinases
Crohn Disease--diagnosis
Disease Models, Animal
Humans
Ileitis--diagnosis
Ileum--enzymology
Inositol Polyphosphate 5-Phosphatases
Interleukin-18--metabolism
Interleukin-1beta--genetics
Leukocytes, Mononuclear--enzymology
Macrophages--enzymology
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
Phosphatidylinositol 3-Kinases--metabolism
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Phosphoinositide-3 Kinase Inhibitors
Phosphoric Monoester Hydrolases--deficiency
Protein Kinase Inhibitors--pharmacology
Receptors, Interleukin-1--antagonists & inhibitors
Transcription, Genetic
Up-Regulation