Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia.

Rzemieniec, J

Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia. [electronic resource] - Molecular neurobiology 10 2016 - 5591-606 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1559-1182

10.1007/s12035-015-9471-0 doi


Animals
Apoptosis--drug effects
Aryl Hydrocarbon Receptor Nuclear Translocator--genetics
Caspase 3--metabolism
Cell Hypoxia--drug effects
Cell Survival--drug effects
Cells, Cultured
Cytochrome P-450 CYP1A1--metabolism
Enzyme Activation--drug effects
Estrogen Receptor beta--agonists
Gene Silencing--drug effects
Hippocampus--metabolism
Indoles--pharmacology
L-Lactate Dehydrogenase--metabolism
Membrane Potential, Mitochondrial--drug effects
Mice
Microtubule-Associated Proteins--metabolism
Neurons--cytology
Neuroprotection--drug effects
RNA, Messenger--genetics
RNA, Small Interfering--metabolism
Reactive Oxygen Species--metabolism
Receptors, Aryl Hydrocarbon--genetics
Signal Transduction--drug effects
Staining and Labeling