Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways.
Hsieh, Hsiao-Yen
Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways. [electronic resource] - Cancer letters Jan 2016 - 56-65 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1872-7980
10.1016/j.canlet.2015.09.018 doi
Angiopoietin-Like Protein 4
Angiopoietins--genetics
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cyproheptadine--pharmacology
G1 Phase Cell Cycle Checkpoints--drug effects
Glycogen Synthase Kinase 3--antagonists & inhibitors
Glycogen Synthase Kinase 3 beta
Humans
Mice
Mice, Inbred BALB C
Receptors, Serotonin--analysis
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Proteins--physiology
Urinary Bladder Neoplasms--drug therapy
beta Catenin--antagonists & inhibitors
Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways. [electronic resource] - Cancer letters Jan 2016 - 56-65 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1872-7980
10.1016/j.canlet.2015.09.018 doi
Angiopoietin-Like Protein 4
Angiopoietins--genetics
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cyproheptadine--pharmacology
G1 Phase Cell Cycle Checkpoints--drug effects
Glycogen Synthase Kinase 3--antagonists & inhibitors
Glycogen Synthase Kinase 3 beta
Humans
Mice
Mice, Inbred BALB C
Receptors, Serotonin--analysis
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Proteins--physiology
Urinary Bladder Neoplasms--drug therapy
beta Catenin--antagonists & inhibitors