Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug resistance in human hepatoma cells.

Sun, Yuqi

Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug resistance in human hepatoma cells. [electronic resource] - European journal of pharmacology Dec 2015 - 28-40 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0712

10.1016/j.ejphar.2015.10.003 doi


ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
Adenosine Triphosphate--metabolism
Animals
Apoptosis--drug effects
Biological Transport--drug effects
Body Weight--drug effects
Carcinoma, Hepatocellular--pathology
Caspase 3--metabolism
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Curcumin--metabolism
Dose-Response Relationship, Drug
Drug Resistance, Multiple--drug effects
Drug Resistance, Neoplasm--drug effects
Drug Synergism
Enzyme Activation--drug effects
Fluorouracil--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Humans
Intracellular Space--drug effects
Liver Neoplasms--pathology
Male
Membrane Potential, Mitochondrial--drug effects
Mice
Mice, Inbred BALB C
Triterpenes--pharmacology
Xenograft Model Antitumor Assays