Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors.
Meulendijks, Didier
Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Feb 2016 - 858-67 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
1557-3265
10.1158/1078-0432.CCR-15-1506 doi
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal--pharmacokinetics
Antibodies, Monoclonal, Humanized
Antineoplastic Agents--pharmacokinetics
Biomarkers, Tumor--blood
Chemokine CCL2--blood
Colorectal Neoplasms--blood
Cytokine TWEAK
Female
Gene Expression
Humans
Male
Matrix Metalloproteinase 9--blood
Maximum Tolerated Dose
Middle Aged
Receptors, Tumor Necrosis Factor--blood
TNF Receptor-Associated Factor 1--metabolism
TWEAK Receptor
Treatment Outcome
Tumor Necrosis Factor Inhibitors
Young Adult
Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Feb 2016 - 858-67 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
1557-3265
10.1158/1078-0432.CCR-15-1506 doi
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal--pharmacokinetics
Antibodies, Monoclonal, Humanized
Antineoplastic Agents--pharmacokinetics
Biomarkers, Tumor--blood
Chemokine CCL2--blood
Colorectal Neoplasms--blood
Cytokine TWEAK
Female
Gene Expression
Humans
Male
Matrix Metalloproteinase 9--blood
Maximum Tolerated Dose
Middle Aged
Receptors, Tumor Necrosis Factor--blood
TNF Receptor-Associated Factor 1--metabolism
TWEAK Receptor
Treatment Outcome
Tumor Necrosis Factor Inhibitors
Young Adult