Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity.

Quast, Isaak

Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity. [electronic resource] - The Journal of clinical investigation Nov 2015 - 4160-70 p. digital

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1558-8238

10.1172/JCI82695 doi


Animals
Antibody-Dependent Cell Cytotoxicity
Antigens, CD20--immunology
B-Lymphocytes--immunology
Burkitt Lymphoma--pathology
Cell Line, Tumor
Complement C1q--immunology
Complement Pathway, Classical
Complement System Proteins--immunology
Cytotoxicity, Immunologic
Glycosylation
Humans
Immunoglobulin G--chemistry
Immunoglobulin gamma-Chains--chemistry
Immunoglobulins, Intravenous--therapeutic use
Killer Cells, Natural--immunology
Lymphocyte Depletion
Mice
Myelin-Oligodendrocyte Glycoprotein--immunology
N-Acetylneuraminic Acid--chemistry
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating--immunology
Protein Processing, Post-Translational
Receptors, IgG--immunology
Rituximab--chemistry