Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial.

Trimble, Cornelia L

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. [electronic resource] - Lancet (London, England) Nov 2015 - 2078-2088 p. digital

Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

1474-547X

10.1016/S0140-6736(15)00239-1 doi


Adult
Cancer Vaccines--immunology
DNA-Binding Proteins--genetics
Double-Blind Method
Female
Human papillomavirus 16--genetics
Human papillomavirus 18--genetics
Humans
Oncogene Proteins, Viral--genetics
Papillomavirus E7 Proteins--genetics
Papillomavirus Infections--drug therapy
Papillomavirus Vaccines--immunology
Repressor Proteins--genetics
Treatment Outcome
Uterine Cervical Neoplasms--drug therapy
Vaccines, DNA--immunology
Young Adult
Uterine Cervical Dysplasia--drug therapy