Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

Mu, Xueru

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment. [electronic resource] - The Journal of clinical investigation Oct 2015 - 3891-903 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1558-8238

10.1172/JCI77995 doi


Animals
Bile Ducts--cytology
Biomarkers, Tumor--analysis
Carbon Tetrachloride--toxicity
Carcinogens
Cell Dedifferentiation
Cell Lineage
Cocarcinogenesis
Comparative Genomic Hybridization
Diethylnitrosamine
Gene Expression Profiling
Genes, Reporter
Hepatocytes--chemistry
Keratin-19--analysis
Liver Cirrhosis, Experimental--pathology
Liver Neoplasms, Experimental--chemically induced
Male
Mice
Mice, Transgenic
Microfilament Proteins--analysis
Neoplastic Stem Cells--chemistry
Osteopontin--analysis
PTEN Phosphohydrolase--deficiency
Precancerous Conditions--chemically induced
Tamoxifen--pharmacology
alpha-Fetoproteins--analysis