A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.

Wu, Ling

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis. [electronic resource] - The Journal of experimental medicine Sep 2015 - 1571-87 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1540-9538

10.1084/jem.20150204 doi


Adaptor Proteins, Signal Transducing--genetics
Animals
Carcinoma, Squamous Cell--metabolism
Cell Proliferation--genetics
Feedback, Physiological
Humans
Interleukin-17--genetics
Keratinocytes--metabolism
MAP Kinase Kinase Kinase 3--genetics
Membrane Proteins--genetics
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mitogen-Activated Protein Kinase 7--genetics
Phosphoproteins--genetics
Receptors, Interleukin-17--genetics
Signal Transduction
Skin Neoplasms--metabolism
TNF Receptor-Associated Factor 4--genetics
Trans-Activators--genetics