LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment.

Li, Meng-Lin

LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment. [electronic resource] - Experimental neurology Nov 2015 - 190-201 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1090-2430

10.1016/j.expneurol.2015.08.019 doi


Amino Acids, Dicarboxylic--pharmacology
Animals
Attention--drug effects
Bridged Bicyclo Compounds--pharmacology
Dizocilpine Maleate--toxicity
Dose-Response Relationship, Drug
Excitatory Amino Acid Agents--pharmacology
Gene Expression Regulation--drug effects
Immunosuppressive Agents--pharmacology
In Vitro Techniques
MAP Kinase Signaling System--drug effects
Male
Memory Disorders--chemically induced
Memory, Short-Term--drug effects
Patch-Clamp Techniques
Prefrontal Cortex--drug effects
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate--genetics
Sirolimus--pharmacology
Synaptic Membranes--drug effects
Synaptic Potentials--drug effects