Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor.

Jiang, Xiaowei

Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor. [electronic resource] - Journal of virology Nov 2015 - 11457-72 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1098-5514

10.1128/JVI.01384-15 doi


Amino Acid Sequence
Base Sequence
CCR5 Receptor Antagonists--therapeutic use
Clinical Trials as Topic
Cyclohexanes--therapeutic use
Drug Resistance, Viral--genetics
Glycosylation
HIV Envelope Protein gp120--genetics
HIV Envelope Protein gp41--genetics
HIV Fusion Inhibitors--therapeutic use
HIV Infections--drug therapy
HIV-1--drug effects
Humans
Maraviroc
Molecular Sequence Data
Protein Structure, Tertiary
Receptors, CCR5--metabolism
Receptors, CXCR4--metabolism
Sequence Alignment
Sequence Analysis, RNA
Signal Transduction--genetics
Treatment Failure
Triazoles--therapeutic use
Virus Internalization--drug effects
Virus Replication--genetics