Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.

Xiao, Qingli

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Sep 2015 - 12137-51 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.0705-15.2015 doi


Amyloid beta-Peptides--genetics
Amyloid beta-Protein Precursor--genetics
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors--genetics
Brain--pathology
Calcium-Binding Proteins--metabolism
Cell Line, Tumor
Dependovirus--genetics
Disease Models, Animal
Gene Expression Regulation--genetics
Glial Fibrillary Acidic Protein--metabolism
Green Fluorescent Proteins--genetics
Lysosomes--genetics
Mice
Mice, Transgenic
Microfilament Proteins--metabolism
Mutation--genetics
Neuroblastoma--pathology
Neurons--metabolism
Plaque, Amyloid--genetics
Presenilin-1--genetics