Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain.

Caires, Rebeca

Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain. [electronic resource] - Nature communications Aug 2015 - 8095 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-1723

10.1038/ncomms9095 doi


Adjuvants, Immunologic--pharmacology
Animals
Behavior, Animal--drug effects
Bradykinin--pharmacology
CHO Cells
Calcium--metabolism
Capsaicin--pharmacology
Cell Line, Tumor
Cricetulus
Ganglia, Spinal--cytology
HEK293 Cells
Hot Temperature
Humans
Hyaluronic Acid--pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Electron
Models, Molecular
Mutagenesis, Site-Directed
Neurons--drug effects
Nociceptive Pain
Nociceptors--drug effects
Patch-Clamp Techniques
Rats
Rats, Wistar
Sensory System Agents--pharmacology
Stifle--drug effects
TRPA1 Cation Channel
TRPM Cation Channels--drug effects
TRPV Cation Channels--drug effects
Transient Receptor Potential Channels--drug effects
Vasodilator Agents--pharmacology