RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.

Hrustanovic, Gorjan

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. [electronic resource] - Nature medicine Sep 2015 - 1038-47 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1546-170X

10.1038/nm.3930 doi


Anaplastic Lymphoma Kinase
Cell Line, Tumor
Drug Resistance, Neoplasm
Dual Specificity Phosphatase 6--physiology
Humans
Lung Neoplasms--drug therapy
Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors
Mitogen-Activated Protein Kinases--physiology
Oncogene Proteins, Fusion--analysis
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins p21(ras)
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
ras Proteins--genetics