New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK.

Di Paolo, Daniela

New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK. [electronic resource] - Oncotarget Oct 2015 - 28774-89 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1949-2553

10.18632/oncotarget.4342 doi


Anaplastic Lymphoma Kinase
Animals
Antineoplastic Agents--pharmacokinetics
Biological Availability
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Combined Modality Therapy
Dose-Response Relationship, Drug
Female
Gene Expression Regulation, Enzymologic--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Half-Life
Humans
Liposomes
Male
Mice, Inbred BALB C
Mice, Nude
Molecular Targeted Therapy
Mutation
Nanoparticles
Neuroblastoma--enzymology
Protein Kinase Inhibitors--pharmacokinetics
RNA Interference
RNA, Small Interfering--genetics
RNAi Therapeutics
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
Signal Transduction--drug effects
Transfection
Tumor Burden--drug effects
Xenograft Model Antitumor Assays