Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms.

de Melo Nunes, Rodolfo

Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. [electronic resource] - Inflammation research : official journal of the European Histamine Research Society ... [et al.] Oct 2015 - 781-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1420-908X

10.1007/s00011-015-0860-7 doi


Analgesics, Non-Narcotic--therapeutic use
Animals
Arthralgia--drug therapy
Chemokine CXCL1--metabolism
Cytokines--metabolism
Dose-Response Relationship, Drug
Injections, Intra-Articular
Interleukin-1beta--metabolism
Joints--pathology
Naloxone--therapeutic use
Narcotic Antagonists--pharmacology
Osteoarthritis--drug therapy
Pain Measurement
Rats
Rats, Wistar
Receptors, Opioid--drug effects
Thiophenes--therapeutic use
Tumor Necrosis Factor-alpha--metabolism