mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells.

Huijts, Charlotte M

mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Sep 2015 - 2038-45 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1550-6606

10.4049/jimmunol.1402710 doi


Active Transport, Cell Nucleus--drug effects
CTLA-4 Antigen--immunology
Cell Line
Cell Nucleus--immunology
Cell Proliferation--drug effects
Cells, Cultured
Dendritic Cells--drug effects
Flow Cytometry
Forkhead Transcription Factors--immunology
Humans
Immunosuppressive Agents--immunology
Interferon-gamma--immunology
Interleukin-10--immunology
Monocytes--drug effects
Natural Killer T-Cells--immunology
Sirolimus--immunology
T-Lymphocytes--immunology
T-Lymphocytes, Regulatory--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors