A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis.

Leung, Kin-Mei

A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. [electronic resource] - Molecular therapy : the journal of the American Society of Gene Therapy Nov 2015 - 1722-1733 p. digital

Publication Type: Journal Article

1525-0024

10.1038/mt.2015.127 doi


Animals
Antibodies, Monoclonal--therapeutic use
Antibodies, Monoclonal, Humanized--pharmacology
Antineoplastic Agents--pharmacology
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Cell Proliferation
Humans
Immunoglobulin Fc Fragments--pharmacology
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasms--drug therapy
Receptor, ErbB-2--antagonists & inhibitors
Signal Transduction
Trastuzumab--pharmacology
Xenograft Model Antitumor Assays