A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf, E M
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer. [electronic resource] - Annals of oncology : official journal of the European Society for Medical Oncology Oct 2015 - 2141-9 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1569-8041
10.1093/annonc/mdv309 doi
Adenocarcinoma, Clear Cell--blood
Adenocarcinoma, Mucinous--blood
Adult
Aged
Antibodies, Monoclonal, Humanized--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Biomarkers, Tumor--blood
CA-125 Antigen--blood
Carboplatin--administration & dosage
Cystadenocarcinoma, Serous--blood
Dose-Response Relationship, Drug
Doxorubicin--administration & dosage
Endometrial Neoplasms--blood
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Interferon alpha-2
Interferon-alpha--administration & dosage
Interferon-gamma--blood
Interleukin-6--blood
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local--blood
Neoplasm Staging
Ovarian Neoplasms--blood
Polyethylene Glycols--administration & dosage
Prognosis
Receptors, Interleukin-6--antagonists & inhibitors
Recombinant Proteins--administration & dosage
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer. [electronic resource] - Annals of oncology : official journal of the European Society for Medical Oncology Oct 2015 - 2141-9 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1569-8041
10.1093/annonc/mdv309 doi
Adenocarcinoma, Clear Cell--blood
Adenocarcinoma, Mucinous--blood
Adult
Aged
Antibodies, Monoclonal, Humanized--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Biomarkers, Tumor--blood
CA-125 Antigen--blood
Carboplatin--administration & dosage
Cystadenocarcinoma, Serous--blood
Dose-Response Relationship, Drug
Doxorubicin--administration & dosage
Endometrial Neoplasms--blood
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Interferon alpha-2
Interferon-alpha--administration & dosage
Interferon-gamma--blood
Interleukin-6--blood
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local--blood
Neoplasm Staging
Ovarian Neoplasms--blood
Polyethylene Glycols--administration & dosage
Prognosis
Receptors, Interleukin-6--antagonists & inhibitors
Recombinant Proteins--administration & dosage