Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease.

Zhang, Yue

Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease. [electronic resource] - Scientific reports Jul 2015 - 12480 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2045-2322

10.1038/srep12480 doi


Angiotensin II--metabolism
Animals
Dinoprostone--metabolism
Electron Transport Complex I--antagonists & inhibitors
Epithelial Sodium Channels--genetics
Gene Expression Regulation
Kidney--drug effects
Kidney Diseases--drug therapy
Male
Mice
Mice, Inbred C57BL
Mitochondria--drug effects
Natriuretic Peptide, Brain--metabolism
Nitric Oxide--metabolism
Nitric Oxide Synthase Type II--genetics
Rotenone--pharmacology
Signal Transduction
Sodium-Hydrogen Exchanger 3
Sodium-Hydrogen Exchangers--genetics
Sodium-Potassium-Exchanging ATPase--genetics
Solute Carrier Family 12, Member 1--agonists
Solute Carrier Family 12, Member 3--genetics
Ureteral Obstruction--genetics