Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.

Iwaoka, Emiko

Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels. [electronic resource] - Journal of natural medicines Jan 2016 - 1-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1861-0293

10.1007/s11418-015-0929-1 doi


Alkaloids--pharmacology
Analgesics--pharmacology
Animals
Calcium--metabolism
Calcium Channels--metabolism
Capsaicin--analogs & derivatives
Dose-Response Relationship, Drug
Evodia--chemistry
Ganglia, Spinal--physiology
HEK293 Cells
Hot Temperature
Humans
Hyperalgesia--chemically induced
Male
Medicine, Chinese Traditional
Nerve Tissue Proteins--metabolism
Neurons--drug effects
Patch-Clamp Techniques
Plant Extracts--pharmacology
Quinazolines--pharmacology
Quinolines--pharmacology
Rats
Rats, Sprague-Dawley
TRPA1 Cation Channel
TRPV Cation Channels--agonists
Transient Receptor Potential Channels--metabolism