KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Dettmer, Ulf

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Aug 2015 - 9596-601 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1091-6490

10.1073/pnas.1505953112 doi


Amino Acid Motifs
Amino Acid Sequence
Animals
Cell Death--drug effects
Conserved Sequence
Cross-Linking Reagents--pharmacology
Humans
Inclusion Bodies--drug effects
Microscopy, Fluorescence
Molecular Sequence Data
Mutant Proteins--metabolism
Mutation--genetics
Neurons--drug effects
Protein Multimerization
Rats, Sprague-Dawley
Repetitive Sequences, Amino Acid
Sequence Deletion
Structure-Activity Relationship
alpha-Synuclein--chemistry