A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.
Dietlein, Felix
A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. [electronic resource] - Cell Jul 2015 - 146-59 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-4172
10.1016/j.cell.2015.05.053 doi
Adenocarcinoma--drug therapy
Adenocarcinoma of Lung
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle Checkpoints
Checkpoint Kinase 1
DNA Damage
Disease Models, Animal
Drug Synergism
Enzyme Inhibitors--pharmacology
Heterografts
Humans
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Lung Neoplasms--drug therapy
Mice
Neoplasm Transplantation
Protein Kinases--metabolism
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins B-raf--metabolism
Proto-Oncogene Proteins p21(ras)
Tumor Cells, Cultured
ras Proteins--metabolism
A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. [electronic resource] - Cell Jul 2015 - 146-59 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-4172
10.1016/j.cell.2015.05.053 doi
Adenocarcinoma--drug therapy
Adenocarcinoma of Lung
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle Checkpoints
Checkpoint Kinase 1
DNA Damage
Disease Models, Animal
Drug Synergism
Enzyme Inhibitors--pharmacology
Heterografts
Humans
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Lung Neoplasms--drug therapy
Mice
Neoplasm Transplantation
Protein Kinases--metabolism
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins B-raf--metabolism
Proto-Oncogene Proteins p21(ras)
Tumor Cells, Cultured
ras Proteins--metabolism