Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies.
Moilanen, Anu-Maarit
Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. [electronic resource] - Scientific reports Jul 2015 - 12007 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep12007 doi
Androgen Receptor Antagonists--pharmacology
Androgens--physiology
Animals
Antineoplastic Agents--pharmacokinetics
Cell Line, Tumor
Drug Resistance, Neoplasm
HEK293 Cells
Humans
Male
Mice, Inbred BALB C
Mice, Nude
Prostatic Neoplasms--drug therapy
Pyrazoles--pharmacokinetics
Receptors, Androgen--metabolism
Signal Transduction
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. [electronic resource] - Scientific reports Jul 2015 - 12007 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep12007 doi
Androgen Receptor Antagonists--pharmacology
Androgens--physiology
Animals
Antineoplastic Agents--pharmacokinetics
Cell Line, Tumor
Drug Resistance, Neoplasm
HEK293 Cells
Humans
Male
Mice, Inbred BALB C
Mice, Nude
Prostatic Neoplasms--drug therapy
Pyrazoles--pharmacokinetics
Receptors, Androgen--metabolism
Signal Transduction
Tumor Burden--drug effects
Xenograft Model Antitumor Assays