A New VMAT-2 Inhibitor NBI-641449 in the Treatment of Huntington Disease.

Chen, Sheng

A New VMAT-2 Inhibitor NBI-641449 in the Treatment of Huntington Disease. [electronic resource] - CNS neuroscience & therapeutics Aug 2015 - 662-71 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1755-5949

10.1111/cns.12425 doi


3,4-Dihydroxyphenylacetic Acid--metabolism
Animals
Cell Survival--drug effects
Corpus Striatum--drug effects
DNA-Binding Proteins
Disease Models, Animal
Dopamine--metabolism
Dopamine and cAMP-Regulated Phosphoprotein 32--metabolism
Dose-Response Relationship, Drug
Female
Homovanillic Acid--metabolism
Huntington Disease--drug therapy
Mice, Transgenic
Motor Activity--drug effects
Nerve Tissue Proteins--metabolism
Neurons--drug effects
Neuroprotective Agents--pharmacology
Nuclear Proteins--metabolism
Serotonin Plasma Membrane Transport Proteins--metabolism
Tyrosine 3-Monooxygenase--metabolism
Vesicular Monoamine Transport Proteins--antagonists & inhibitors