Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.

Fonseca, Emanuella M B

Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. [electronic resource] - Bioorganic & medicinal chemistry Aug 2015 - 4462-4471 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3391

10.1016/j.bmc.2015.06.017 doi


Binding Sites
Catalytic Domain
Crystallography, X-Ray
Humans
Kinetics
Molecular Docking Simulation
Phosphorous Acids--chemistry
Protein Tyrosine Phosphatases--chemistry
Proto-Oncogene Proteins--chemistry
Recombinant Proteins--biosynthesis
Substrate Specificity
Sulfonic Acids--chemistry