Discovery and characterization of a potent and selective EP4 receptor antagonist.

Schiffler, Matthew A

Discovery and characterization of a potent and selective EP4 receptor antagonist. [electronic resource] - Bioorganic & medicinal chemistry letters Aug 2015 - 3176-8 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2015.05.091 doi


Analgesics--chemistry
Animals
Blood Cells--cytology
Dogs
Half-Life
Humans
Lipopolysaccharides--toxicity
Protein Binding
Receptors, Prostaglandin E, EP4 Subtype--antagonists & inhibitors
Structure-Activity Relationship
Tumor Necrosis Factor-alpha--metabolism