JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cells.

Keohane, Clodagh

JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cells. [electronic resource] - British journal of haematology Oct 2015 - 60-73 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1365-2141

10.1111/bjh.13519 doi


Cytokines--immunology
Female
Humans
Janus Kinases--antagonists & inhibitors
Male
Myeloproliferative Disorders--drug therapy
Nitriles
Protein Kinase Inhibitors--administration & dosage
Pyrazoles--administration & dosage
Pyrimidines
Pyrrolidines--administration & dosage
Sulfonamides--administration & dosage
T-Lymphocytes, Regulatory--enzymology
Th17 Cells--enzymology
Time Factors
Tumor Cells, Cultured