Novel Mechanisms for the Antifibrotic Action of Nintedanib.

Rangarajan, Sunad

Novel Mechanisms for the Antifibrotic Action of Nintedanib. [electronic resource] - American journal of respiratory cell and molecular biology Jan 2016 - 51-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1535-4989

10.1165/rcmb.2014-0445OC doi


Apoptosis Regulatory Proteins--genetics
Autophagy-Related Protein 7
Beclin-1
Cells, Cultured
Collagen Type I--genetics
Collagen Type I, alpha 1 Chain
Dose-Response Relationship, Drug
Fibronectins--genetics
Humans
Idiopathic Pulmonary Fibrosis--genetics
Indoles--pharmacology
Lung--drug effects
Membrane Proteins--genetics
Phosphorylation
Protein Serine-Threonine Kinases--metabolism
RNA Interference
RNA, Messenger--metabolism
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta--metabolism
Signal Transduction--drug effects
Smad3 Protein--metabolism
Time Factors
Transfection
Transforming Growth Factor beta1--metabolism
Ubiquitin-Activating Enzymes--genetics
p38 Mitogen-Activated Protein Kinases--metabolism