Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.

Tanaka, Ryoichi

Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells. [electronic resource] - PloS one 2015 - e0125779 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0125779 doi


Antineoplastic Agents--toxicity
Apoptosis--drug effects
Apoptosis Regulatory Proteins--metabolism
Bcl-2-Like Protein 11
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclin-Dependent Kinase Inhibitor p27--metabolism
Down-Regulation--drug effects
Drug Resistance, Neoplasm--drug effects
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Membrane Proteins--metabolism
Metformin--toxicity
MicroRNAs--antagonists & inhibitors
Oligonucleotides, Antisense--metabolism
Pancreatic Neoplasms--metabolism
Proto-Oncogene Proteins--metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand--metabolism
TNF-Related Apoptosis-Inducing Ligand--toxicity
Tumor Suppressor Protein p53--genetics
Up-Regulation--drug effects