Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.

Deng, Zihou

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. [electronic resource] - Nature immunology Jun 2015 - 642-52 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1529-2916

10.1038/ni.3155 doi


Amino Acid Motifs--genetics
Animals
Antigens, Fungal--immunology
Candidiasis--immunology
Cells, Cultured
Cytokines--metabolism
Dendritic Cells--physiology
Enzyme Activation
Inflammation Mediators--metabolism
Intracellular Signaling Peptides and Proteins--metabolism
Lectins, C-Type--genetics
Lymphocyte Activation
Macrophages--physiology
Membrane Proteins--genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutation--genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 11--genetics
Protein-Tyrosine Kinases--metabolism
Receptors, IgE--genetics
Signal Transduction
Syk Kinase
T-Lymphocytes, Helper-Inducer--immunology
Th17 Cells--immunology