Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.
Hiraoka, Kiriko
Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. [electronic resource] - Nature communications Apr 2015 - 6706 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-1723
10.1038/ncomms7706 doi
Animals
Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Caco-2 Cells
Cellular Senescence--drug effects
DNA Damage
Drug Evaluation, Preclinical
Female
HT29 Cells
Humans
Imidazoles--chemical synthesis
Mice, Nude
Mutation
Neoplasms, Experimental--drug therapy
Nylons--chemical synthesis
Proto-Oncogene Proteins p21(ras)--antagonists & inhibitors
Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. [electronic resource] - Nature communications Apr 2015 - 6706 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-1723
10.1038/ncomms7706 doi
Animals
Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Caco-2 Cells
Cellular Senescence--drug effects
DNA Damage
Drug Evaluation, Preclinical
Female
HT29 Cells
Humans
Imidazoles--chemical synthesis
Mice, Nude
Mutation
Neoplasms, Experimental--drug therapy
Nylons--chemical synthesis
Proto-Oncogene Proteins p21(ras)--antagonists & inhibitors