SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.

Pasquier, Benoit

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. [electronic resource] - Autophagy Apr 2015 - 725-6 p. digital

Publication Type: Journal Article

1554-8635

10.1080/15548627.2015.1033601 doi


Autophagy--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Class III Phosphatidylinositol 3-Kinases--metabolism
Endosomes--drug effects
Humans
Lysosomes--drug effects
Phagosomes--metabolism
Protein Kinase Inhibitors--pharmacology
Pyridines--pharmacology
Pyrimidinones--pharmacology
TOR Serine-Threonine Kinases--antagonists & inhibitors