A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy.

Borthakur, Gautam

A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy. [electronic resource] - Haematologica Jul 2015 - 898-904 p. digital

Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

1592-8721

10.3324/haematol.2014.115279 doi


Adult
Aged
Aged, 80 and over
Antineoplastic Agents--administration & dosage
Benzamides--administration & dosage
Blast Crisis--drug therapy
Drug Administration Schedule
Febrile Neutropenia--chemically induced
Female
Fusion Proteins, bcr-abl--genetics
Humans
Imatinib Mesylate--administration & dosage
Leukemia, Myeloid, Accelerated Phase--drug therapy
Male
Middle Aged
Mucositis--chemically induced
Mutation
Philadelphia Chromosome
Protein Kinase Inhibitors--administration & dosage
Pyrazoles--administration & dosage